Researchers used a novel phosphate-activation reagent, 2-MeImIm-Cl, in an improved coupling reaction to increase the yield of ADP- or ATP-containing molecules. Unlike traditional reactions, the ...

A so-called "molecular chaperone", the protein Hsp70, carries out more functions in the maturation of proteins than previously thought. As the researchers have discovered, Hsp70 not only acts as a ...

Key nuclear processes in eukaryotes, including DNA replication, repair, and gene regulation, require extensive chromatin remodeling catalyzed by energy-consuming enzymes. It remains unclear how the ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 23 (June 7, 2022), pp. 1-11 (11 pages) Adenosine diphosphate (ADP) ribosylation is a reversible ...

New research led by a team from the Sabri Ülker Center for Metabolic Research at the Harvard T.H. Chan School of Public Health identified a new hormone named fabkin that helps regulate metabolism and ...

To ensure homeostasis in the brain, microglia are constantly feeling about with their finger-like processes, making sure that all is well, or sensing problems and rearing up to help. A study in ...