Telomir Pharmaceuticals Announces New Findings in a Prostate Cancer Model Demonstrating Telomir-1 Also Resets DNA Methylation of Tumor Suppressor Gene…

Findings show that Telomir-1 restores the body’s natural tumor suppressor defenses by reversing abnormal DNA methylation of ...
EurekAlert!

Identification of p53-SET-PP2A feedback loop for cancer therapy

This study is led by Dr. Donglai Wang (Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College) and Dr. Wei-Guo Zhu (Shenzhen ...
Nature

Suppressor of cytokine signaling-1 is an IL-4-inducible gene in macrophages and feedback inhibits IL-4 signaling

We have previously shown that type-I and -II interferons induce SOCS-1 expression in monocytes. 8 To determine if IL-4 itself can induce expression of SOCS-1 in monocytes, we treated normal human ...
Nature

Arf tumor suppressor disrupts the oncogenic positive feedback loop including c-Myc and DDX5

Tumor suppressor protein p19 ARF (Arf; p14 ARF in humans) functions in both p53-dependent and -independent modes to counteract hyper-proliferative signals caused by proto-oncogene activation, but its ...