The inflammasome — a protein signaling network that is activated to rid the body of virus or bacteria-infected cells — may play an important role in triggering an immune response to cancer and causing ...

SARS-CoV-2, which belongs to the family Coronaviridae, is a highly infectious virus that mainly infects the respiratory tract of humans. The viral genome of SARS-CoV-2 is found within the nucleocapsid ...

NEWTON, Mass.--(BUSINESS WIRE)--Inflammasome Therapeutics, a private company, has completed enrollment of a Phase I PK/Safety study of its new brain- and retina-penetrant drug K9, which has ...

Microglia have been firmly linked to amyloid plaques, but scientists are only beginning to examine their relationship to tau tangles. In the November 20 Nature, Michael Heneka and colleagues at the ...

Inflammation plays a critical role in both acute and long term SARS-CoV-2 infection, as well as many of the most serious chronic diseases, such as Alzheimer’s, type 2 diabetes, and atherosclerosis.

Aspiring to become the leader in inflammasome-targeted therapeutics, Novartis will acquire IFM Tre, a subsidiary of Boston-based IFM Therapeutics, in a deal worth up to $1.6 billion. The purchase ...

NEWTON, Mass.--(BUSINESS WIRE)--Inflammasome Therapeutics (https://www.inflam.com), a clinical-stage, private company developing a new class of inflammasome inhibitor drugs, Kamuvudines, as therapies ...

The paper: S. Mariathasan et al., "Cryopyrin activates the inflammasome in response to toxins and ATP," Nature, 440:228-32, 2006. (Cited in 121 papers) The finding: By observing mice deficient in the ...

Neushen Therapeutics Inc. has patented NLRP3 inflammasome inhibitors reported to be useful for the treatment of Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral ...

Roche RHHBY acquired Dublin-based biotech company Inflazome for an upfront payment of €380 million. Inflazome’s shareholders are also eligible to receive additional contingent payments to be made ...