Rob Lowe is ready to be crowned PEOPLE's Sexiest Man Alive — so much so that he lamented never gracing the cover during the ...

Rob Lowe and Melissa Gilbert met as teenagers, but their powerful chemistry led to a turbulent romance that ended in devastating circumstances ...

John Owen also pranked his dad in front of a national audience in 2019, when he wrote disses backstage while Rob Lowe was being interviewed on "The Ellen DeGeneres Show" and shared them on screen.