Drug conjugates (ADCs) developed at Institute of Science Tokyo combine a CD4 mimic with neutralizing antibodies for enhanced suppression of human immunodeficiency virus (HIV) infection. By targeting ...

Early in the pandemic, most research, including our own, focused on designing drugs that could block the virus's spike protein. This was a logical first step, but as we've seen, the virus is a moving ...

This image shows the HIV-1 capsid as it passes through the cell's nuclear pore complex, in the process known as nuclear entry. Once inside the nucleus, the capsid uncoats, releasing the viral genome ...

Researchers at WashU Medicine have identified key entry routes that two deadly viruses use to infect cells. Shown are mouse neurons and their cell nuclei (purple and blue). On the left, infection with ...