Most human cases of bird flu in North America have been mild, a fact that’s underscored by a new study of the first 46 confirmed human H5N1 infections in the United States this year. But the case of an ill Canadian teen stands out because of its severity and because the source of exposure remains a mystery.

Genetic analysis of H5N1 bird flu viruses from a severely ill patient in Louisiana revealed multiple mutations that may enhance the virus’s ability to bind to human upper airway cells, the Centers for Disease Control and Prevention (CDC) reported on Thursday.

In 2024, at least 66 human cases of bird flu have been reported in the United States, each one raising the risk of another pandemic like COVID-19. So far, most cases have been described as “mild,” which means they weren't hospitalized.