Scientists have long known that people with cerebrovascular disease have higher odds of getting Alzheimer’s dementia. What has been harder to find is a good marker of brain vascular dysfunction that ...

If a person with no cognitive complaints tests positive for brain amyloid based on plasma p-tau217, what should their doctor tell them about their likelihood of getting Alzheimer’s disease? That’s the ...

The Alzheimer’s disease field has been abuzz about plasma p-tau217 for a while. This marker of brain amyloid can identify, with a high degree of accuracy, people with AD pathology among the ...

Introduction Despite being arguably the second most common dementing disorder, dementia with Lewy bodies, aka DLB, remains both mysterious and understudied. On Tuesday, October 10, 2017, the Lewy Body ...

Professional Information ProfessorCentre de Neurologie Cognitive - CMRR Paris Nord Comments Without ApoE3 or ApoE4, Alzheimer’s Would be a Rare Disease 23 Jan 2026 ...

Progranulin is an obvious target for a frontotemporal dementia therapy, as up to 15 percent of cases arise from loss-of-function mutations in its gene, GRN. In a study published January 7 in Science ...

Professional Information Dr.McGill University Comments In TDP-43 Proteinopathy, Misplaced PolyA Tails Mean Crippled Retromers 13 Jan 2026 ...

This approach uses mesenchymal stem cells isolated from a patient’s own fat tissue to treat neurodegenerative diseases. The stem cells are supposed to assist in repair of damaged tissue and ...

What makes synapses disappear with age? In the January 21 Nature, scientists led by Tony Wyss-Coray at Stanford University School of Medicine, California, report that sluggish turnover of synaptic ...

Changes in the choroid plexus and ventricles, visible on PET and MRI, suggest problems with waste clearance from the brain that might precede amyloid and tau accumulation.

As awareness about dementia continues to grow worldwide, a spate of online courses aims to help both health professionals and the general public understand Alzheimer’s and related diseases. Below is a ...

These parkin knockout (KO) mice were generated by creating a germline disruption in the parkin gene within exon 3 leading to a truncated transcript coding for the first 95 amino acids of mouse parkin ...