Background Despite biomarker-guided initiation, non- or loss of response to biologic therapy occurs in a minority of patients with severe asthma. In cases of treatment failure, it is important to ...

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be ...

Background Acute type 2 respiratory failure (AT2RF) is the failure of ventilatory mechanism which results in hypercapnia(>6kPa). Current treatment is non-invasive ventilation(NIV) which has a high ...

Background Development of emphysema and vascular stiffness in chronic obstructive pulmonary disease (COPD) may be due to a common mechanism of susceptibility to pulmonary and systemic elastin ...

Air Travel Working Party: Dr R K Coker (chair), Dr D A R Boldy, Dr R Buchdahl, Mr D Cramer, Professor D Denison, Wing Commander D P Gradwell, Professor J M B Hughes, Dr J A Innes, Dr A O C Johnson, Dr ...

Department of Child Health, University of Leicester School of Medicine, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, P O Box 65, Leicester LE2 7LX, UK BACKGROUND The aim of ...

Associations of pulmonary microvascular blood volume with per cent emphysema and CT emphysema subtypes in the community: the MESA Lung study ...

Background The Global Obstructive Lung Disease (GOLD) 2011 revision recommends the multidimensional assessment of COPD including comorbidities and has developed a ...

1 Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for ...

Background Whether inhaled corticosteroids (ICSs) reduce major adverse cardiovascular events (MACEs) in people with chronic obstructive pulmonary disease (COPD) is debated. Objectives To establish, ...

1 Department of Palliative Medicine, Royal Marsden and Royal Brompton NHS Foundation Trusts, London, UK 2 Department of Palliative Care, Policy and Rehabilitation, King's College London, Cicely ...