The role of ApoE has been well-studied outside of the cell, but what happens after it’s let inside? Scientists led by Raimund Dutzler, University of Zurich, have identified Tweety homologue 2 as an ...

Parkinsonian disorders are difficult to diagnose. Clinical symptoms often overlap with criteria for other diseases, and clinicians can only make a definitive diagnosis postmortem. Now, a study ...

Meet the Jekyll and Hyde of the immune system: activated CD8⁺ T cells. On June 24 in Nature Immunology, researchers led by Dorian McGavern at the National Institutes of Health introduce a granzyme ...

Comments ApoE and Tweety Homolog 2—Proteins that Flock Together? 11 Jul 2025 ...

To satisfy the incessant energy demands of their thousands of synapses, neurons have to have enormous supplies of ATP at the ready. Where does this seemingly bottomless well of energy come from? It’s ...

This widely used tauopathy model was developed at the University of Pennsylvania School of Medicine by Virginia Lee, John Trojanowski, and colleagues. As first reported in 2007 on a mixed background, ...

Early onset familial Alzheimer disease (eFAD) is hereditary and marked by Alzheimer disease symptoms that appear at an unusually early age. Symptoms can start in a person's thirties, forties, and ...

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As reported in 1994, the original SOD1-G93A strain, designated G1, expressed approximately 18 copies of human SOD1, randomly inserted into the genome (Gurney et al., 1994). An unequal crossover event ...

Research News Parkinsonian disorders are difficult to diagnose. Clinical symptoms often overlap ...