Gut

Zinc-dependent RNA-binding protein controls hepatocyte senescence and recovery from alcohol-related liver failure

Background Why alcohol-associated liver disease (ALD) resolves after abstinence in most people but progresses to liver ...
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Gut, inflammation and osteoporosis: basic and clinical concepts

1 Christian Doppler Research Laboratory for Gut Inflammation and Department of Medicine, Division of Gastroenterology and Hepatology, Medical University Innsbruck, Austria 2 Department of Medicine “T” ...
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Expression of NOD2 in Paneth cells: a possible link to Crohn’s ileitis

1 Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA 2 Department of Medicine, Royal Free and University College Medical ...
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Newly diagnosed diabetes mellitus after acute pancreatitis: a systematic review and meta-analysis

1 Department of Surgery, The University of Auckland, Auckland, New Zealand 2 Department of Medicine, The University of Auckland, Auckland, New Zealand Correspondence to Dr Maxim S Petrov, Department ...
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Increased uptake and improved outcomes of bowel cancer screening with a faecal immunochemical test: results from a pilot study within the national screening programme in England

3 NHS Bowel Cancer Screening Midlands and North West Programme Hub, Rugby, UK 4 NHS Bowel Cancer Screening Southern Programme Hub, Guildford, UK 5 University of Surrey, Guildford, UK Correspondence to ...
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Genome-wide association scan in north Indians reveals three novel HLA-independent risk loci for ulcerative colitis

Objective Over 100 ulcerative colitis (UC) loci have been identified by genome-wide association studies (GWASs) primarily in Caucasians (CEUs). Many of them have weak effects on disease susceptibility ...
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Gut origin of sepsis: a prospective study investigating associations between bacterial translocation, gastric microflora, and septic morbidity

AIMS To investigate the “gut origin of sepsis” hypothesis. METHODS Prospective controlled study of 279 surgical patients in which cultures of nasogastric aspirates were compared with those obtained ...
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Predicting relapse in Crohn’s disease: a biopsychosocial model

Background: Crohn’s disease (CD) is a chronic relapsing inflammatory bowel disorder. Both biological and psychosocial factors may modulate the illness experience. Aim: The aim of this study was to ...
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CNNM4: a ferroptotic vulnerability in cholangiocarcinoma

Cholangiocarcinoma (CCA) represents one of the most aggressive malignancies affecting the biliary tree, with limited treatment options and high mortality rates. Despite recent advances in molecular ...
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Global consensus statement on the management of pregnancy in inflammatory bowel disease

Background & aims Pregnancy can be a complex and risk filled event for women with inflammatory bowel disease (IBD). High-quality studies in this population are lacking, with limited data on ...
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Treatment of non-constipated irritable bowel syndrome with the histamine 1 receptor antagonist ebastine: a randomised, double-blind, placebo-controlled trial

Correspondence to Professor Guy Boeckxstaens, Department of Chronic Diseases, Metabolism, and Ageing, KU Leuven, Leuven, Belgium; guy.boeckxstaens{at}kuleuven.be Objective We evaluated the histamine 1 ...
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Alleviated T cell exhaustion and SLC1A3-mediated stroma-remodelling dictate chemoimmunotherapy efficacy in oesophageal squamous cell carcinoma

3 Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Chinese Academy of Medical Sciences, Peking Union Medical College, ...