BMJ9h
The Goteborg MCI study: mild cognitive impairment is a heterogeneous condition
Background: Mild cognitive impairment (MCI) has been considered a transitional state between normal aging and dementia, characterised by memory impairment but normal general cognitive functioning.
BMJ21h
Assessment of the severity of head injury.
Ranking of head injuries by severity is an essential part of clinical management, of prognosis, of treatment trials, and of legal assessment for compensation. Various methods of assessing severity are ...
BMJ1d
Deficient saccadic inhibition in Asperger’s disorder and the social-emotional processing disorder
1 Department of Psychiatry and the Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA 2 Department of Psychiatry, ...
BMJ1d
Hippocampal subfield atrophy of CA1 and subicular structures predict progression to dementia in idiopathic Parkinson’s disease
Background Global hippocampal atrophy is a hallmark of Alzheimer’s dementia and has been similarly reported in Parkinson’s disease dementia (PDD). However, there is limited literature on the ...
BMJ3d
Recovery patterns and long term prognosis for axonal Guillain–Barré syndrome
Background: Little is known about the long term prognosis for patients the severe acute motor axonal neuropathy (AMAN) form of Guillain–Barré syndrome (GBS), unlike those with acute inflammatory ...
BMJ9d
Ultra-high-dose methylcobalamin in amyotrophic lateral sclerosis: a long-term phase II/III randomised controlled study
Objective To evaluate the efficacy and safety of intramuscular ultra-high-dose methylcobalamin in patients with amyotrophic lateral sclerosis (ALS). Methods 373 patients with ALS (El Escorial definite ...
BMJ3d
Vasculitic polyradiculopathy in systemic lupus erythematosus
Dr G Midroni, Neurophysiology laboratory, St. Michael’s Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8. Telephone 00416 864 5193; fax 00416 864 6095. A 22 year old woman with recently ...
BMJ3d
Large scale brain models of epilepsy: dynamics meets connectomics
The brain is in a constant state of dynamic change, for example switching between cognitive and behavioural tasks, and between wakefulness and sleep. The brains of people with epilepsy have additional ...
BMJ10d
Data-driven evolution of neurosurgical gene therapy delivery in Parkinson’s disease
Loss of nigrostriatal dopaminergic projection neurons is a key pathology in Parkinson’s disease, leading to abnormal function of basal ganglia motor circuits and the accompanying characteristic motor ...
BMJ9d
Tumefactive demyelination: an approach to diagnosis and management
2 Queen Square MS Centre, Institute of Neurology, University College London, London, UK Correspondence to Dr Todd Hardy, Box 21, National Hospital for Neurology and Neurosurgery, Queen Square, London ...
BMJ4d
Effectiveness of early cycles of fast-acting treatment in generalised myasthenia gravis
Background Early fast-acting treatment (EFT) is the aggressive use of fast-acting therapies such as plasmapheresis, intravenous immunoglobulin and/or intravenous high-dose methylprednisolone (IVMP) ...
BMJ5d
White-matter diffusion abnormalities in temporal-lobe epilepsy with and without mesial temporal sclerosis
Division of Neurology, Department of Medicine, University of Alberta, Alberta, Canada Dr D W Gross, Division of Neurology, Department of Medicine, 2E3.19 Walter C Mackenzie Health Sciences Centre, ...