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Lecanemab Favors Early Aggregates. Fluorescently labeled lecanemab (green) bound most strongly to soluble Aβ aggregates ...

A drug that has been used for nearly a century to prevent and dissolve blood clots may also delay the onset of Alzheimer’s disease, according to a study in the October 8 Molecular Psychiatry. Heparin ...

In this mouse, TREM2 and the fluorescent protein mKate2 are co-expressed under the control of the endogenous Trem2 promoter, allowing researchers to indirectly assess expression of TREM2 by measuring ...

A top researcher’s fall from grace sends shock waves through the scientific community. Such is the case with neuropathologist Eliezer Masliah, who stands accused of image falsification spanning 26 ...

Michael Belloy at Washington University in St. Louis noted that the findings could help distinguish between genes that directly affect pathology, and those that instead help maintain cognition in the ...

For example, Huntington’s disease (HD), the first expansion disorder discovered, occurs when a cysteine-arginine-guanine (CAG) trinucleotide in the HTT gene swells to 40 or more repeats. Such ...

SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available.