Superior Mediastinal Lymph Nodes Superior mediastinal lymph nodes are a group of lymph nodes located in the superior mediastinum, which is the upper part of the chest cavity above the heart. They play a role in filtering lymph fluid from the lungs, airways, and other structures in the chest. These nodes are often assessed during imaging and can be a site for metastasis from lung cancer and other thoracic malignancies. | Dr. Najeeb